Publications

2019

Robb NC, Taylor JM, Kent A, Pambos O, Gilboa B, Kapanidis AN. Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction. BioRxiv.   Link

Robb NC, te Velthuis AJW, Fodor E, Kapanidis AN. Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics.  Nucleic Acids Research Link

2018

Hepp C & Robb NC. Coming together during viral assembly . Nature Reviews Microbiology. 16(12):721 Link

Hellenkamp B, Schmid S, et int., Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods . 15(9):669-676. Link

Duchi D, Gryte K, Robb NC, Morichaud Z, Sheppard C, Brodolin K, Wigneshweraraj S, Kapanidis AN. Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes. Nucleic Acids Research. 46(2):677-688.  Link

 

2016

 

Robb NC, te Velthuis AJW, Wieneke R, Tampè R, Cordes T, Fodor E, Kapanidis AN. Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA. Nucleic Acids Research. 44(21):10304-10315.  Link
 
Duchi D, Bauer DLV, Fernandez L, Evans G, Robb NC, Hwang LC, Gryte K, Tomescu A, Zawadski P, Morichaud Z, Brodolin K, Kapanidis AN. RNA polymerase pausing during initial transcription. Molecular Cell. 63(6):939-50.  Link

 

Te Velthuis AJW, Robb NC, Kapanidis AN, Fodor E. The role of the priming loop in Influenza A virus RNA synthesis.  Nature Microbiology. 1:16029.  Link

 

2014

 

Tomescu AI*, Robb NC*, Hengrung N, Fodor E, Kapanidis AN. Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.  PNAS. 111(32):E3335-42 . (*Joint first authors).  Link

 

2013

 

Robb NC*, Cordes T*, Hwang LC*, Gryte K, Duchi D, Craggs TD, Santoso Y, Weiss S, Ebright RH, Kapanidis AN. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection. J Mol Biol. 425(5):875-85. (*Joint first authors).  Link

 

2012

         

Wise HM, Hutchinson EC, Jagger BW, Stuart, AD, Kang ZH, Robb NC, Kash JC, Fodor, E, Firth AE, Gog JR, Taubenberger JK and Digard P. Identification of a novel splice variant form of the influenza a virus M2 ion channel. PLoS Pathogens. 8(11): e1002998.  Link

 

Robb NC and Fodor E. The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein. J Gen Virol 93(Pt 1):113-8. Link

 

2011

 

Robb NC, Chase G, Bier K, Vreede FT, Shaw P, Naffakh N, Schwemmle M, Fodor E. The influenza A NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes. J Virol. 85(10):5228-31Link

 

2010

      

Wang Z, Robb NC, Lenz E, Wolff T, FodorE, Pleschka S. Reassortment of the NS segment of an H7-type HPAIV affects its propagation by altering the regulation of viral RNA production and the anti-viral host response.  J. Virol . 84(21):11323-35. Link

 

Robb NC, Jackson D, Vreede FT and Fodor E. Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein. J Gen Virol. 91(Pt 9):2331-40.  Link

 

Chan W, Ng A, Robb NC, Lam M, Chan P, Au S, Fodor E, Shaw P. Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol . 84(14):7337-45. Link

 

Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb NC, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I detects viral genomic RNA during negative strand RNA virus infection.  Cell. 140(3):397-408.  Link

 

2009

 

Robb NC*, Smith M*, Vreede FT, Fodor E. (2009) The NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol. 90(Pt 6):139. (*Joint first authors).  Link

 

 

Outreach articles

 

Aartjan te Velthuis & Nicole Robb

The ‘beating heart’ of the flu virus – and why scientists want to commandeer it

The Conversation, 2016.  Link

 

 

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